金属茂的生物化学。羟基乙酰基[103Ru]钌茂及其葡糖醛酸苷在小鼠体内的器官分布。

Biochemistry of metalocenes. The organ distribution of hydroxyacetyl [103Ru]ruthenocene and its glucuronide in mice.

作者信息

Taylor A J, Macha J, Wenzel M

出版信息

J Nucl Med. 1980 Jan;21(1):63-6.

Abstract

Hydroxyacetyl [103Ru]ruthenocene and its o-glucuronide were prepared in vitro by incubation of acetyl [103Ru]ruthenocene with rat-liver homogenate, NADPH, and UDP-glucuronate. The factors affecting hydroxylation and glucuronidation in vitro were optimized for acetylruthenocene. Hydroxyacetyl [103Ru]ruthenocene glucuronide showed no affinity for the adrenal glands, but after i.v. administration of hy droxyacetyl [103Ru]ruthenocene there was a distinct accumulation of Ru-103 in adrenals, similar to that found after administration of acetyl [103Ru]ruthenocene.

摘要

羟基乙酰基[¹⁰³Ru]钌茂及其邻葡萄糖醛酸苷是通过将乙酰基[¹⁰³Ru]钌茂与大鼠肝脏匀浆、烟酰胺腺嘌呤二核苷酸磷酸（NADPH）和尿苷二磷酸葡萄糖醛酸一起孵育在体外制备的。针对乙酰钌茂，对体外影响羟基化和葡萄糖醛酸化的因素进行了优化。羟基乙酰基[¹⁰³Ru]钌茂葡萄糖醛酸苷对肾上腺无亲和力，但静脉注射羟基乙酰基[¹⁰³Ru]钌茂后，肾上腺中出现了明显的¹⁰³Ru积累，这与注射乙酰基[¹⁰³Ru]钌茂后发现的情况相似。

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Biochemistry of metalocenes. The organ distribution of hydroxyacetyl [103Ru]ruthenocene and its glucuronide in mice.

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