二乙基二硫代氨基甲酸钠对丝裂原诱导的体外淋巴细胞增殖的影响
Effect of sodium diethyl dithiocarbamate on mitogen induced lymphoproliferation "in vitro".
作者信息
Neveu P J, Buscot N, Thierry D
出版信息
Biomedicine. 1980 Dec;33(8):247-8.
PMID:6260259
Abstract
Sodium diethyl dithiocarbamate (DTC) is a low molecular weight sulphur compound which has been shown to be an adjuvant of immunity in vivo. In this report, DTC was shown to inhibit in vitro DNA-synthesis of human peripheral blood lymphocytes stimulated by phytohemagglutinin or concanavalin A. DTC could act directly at the cellular level and indirectly by interfering with culture medium or lectins.
摘要
二乙基二硫代氨基甲酸钠（DTC）是一种低分子量的硫化合物，已被证明在体内是一种免疫佐剂。在本报告中，DTC被证明可抑制由植物血凝素或刀豆球蛋白A刺激的人外周血淋巴细胞的体外DNA合成。DTC可直接作用于细胞水平，也可通过干扰培养基或凝集素间接发挥作用。
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