Neveu P J, Perdoux D, Lafleur L
Int J Immunopharmacol. 1982;4(1):9-13. doi: 10.1016/0192-0561(82)90003-0.
Sodium diethyl dithiocarbamate (DTC), a low molecular weight sulphur compound, has been previously shown to be endowed of immunomodulatory properties. To get a better understanding of the mechanisms whereby DTC regulates the immune response, mitogen-induced lymphoproliferation was studied in spleen from guinea pigs treated with a single i.v. injection of DTC. The results clearly show that DTC enhances, after a lag period, DNA synthesis in T and B lymphocytes. DTC which appears not to act at the level of immuno-competent cells seems to modulate the immune responses through indirect pathways.
二乙基二硫代氨基甲酸钠（DTC）是一种低分子量硫化合物，先前已证明它具有免疫调节特性。为了更好地理解DTC调节免疫反应的机制，我们研究了经静脉单次注射DTC处理的豚鼠脾脏中丝裂原诱导的淋巴细胞增殖情况。结果清楚地表明，DTC在一段延迟期后增强了T和B淋巴细胞中的DNA合成。似乎不在免疫活性细胞水平起作用的DTC似乎通过间接途径调节免疫反应。
