百日咳杆菌中百日咳毒素原的结晶
Crystallization of pertussigen from Bordetella pertussis.
作者信息
Arai H, Munoz J J
出版信息
Infect Immun. 1981 Jan;31(1):495-9. doi: 10.1128/iai.31.1.495-499.1981.
Abstract
A method is described for crystallizing pertussigen from Bordetella pertussis. The crystalline material induced histamine hypersensitivity in mice at a dose of 0.5 ng of protein and leukocytosis at a dose of 100 ng and was toxic at a dose of 429 microgram. The histamine-sensitizing activity and the toxicity were as high as ever reported.
摘要
描述了一种从百日咳博德特氏菌中结晶百日咳原的方法。该结晶物质在剂量为0.5纳克蛋白质时可诱导小鼠组胺超敏反应，在剂量为100纳克时可诱导白细胞增多，在剂量为429微克时具有毒性。其组胺致敏活性和毒性与以往报道的一样高。
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