Pittman M
Rev Infect Dis. 1979 May-Jun;1(3):401-12. doi: 10.1093/clinids/1.3.401.
The nature of the pathogenesis and of the prolonged immunity of whooping cough has not been clearly defined. The literature of Bordetella pertussis indicated that only the antigen that induces histamine sensitization, lymphocytosis, and other biological reactions in mice is the cause of the harmful effects and prolonged immunity of whooping cough. This antigen has the general characteristics of bacterial protein exotoxins that cause the harmful effects of infectious diseases such as diphtheria and tetanus. It is proposed that this antigen, which is histamine-sensitizing, lymphocyte-leukocyte-promoting, and islets-activating (HSF-LPF-IAP), be designated pertussis toxin. Agglutinogen, hemagglutinin, and heat-labile (at 56 C) and heat-stable (at 100 C) toxins are no doubt interrelated with the immunologic and/or toxic reactions of whooping cough. It appears that the first defense against the disease is the antibody that prevents adhesion of the bacteria to the cilia of the respiratory epithelium and that the second defense is the antitoxin against pertussis toxin (HSF-LPF-IAP).
百日咳的发病机制及持久免疫力的本质尚未明确界定。关于百日咳博德特氏菌的文献表明，只有那种能在小鼠体内诱发组胺致敏、淋巴细胞增多及其他生物学反应的抗原，才是百日咳产生有害影响及持久免疫力的原因。这种抗原具有细菌蛋白外毒素的一般特征，这类外毒素会引发诸如白喉和破伤风等传染病的有害影响。有人提议，将这种具有组胺致敏、促进淋巴细胞 - 白细胞生成及激活胰岛作用（HSF - LPF - IAP）的抗原命名为百日咳毒素。凝集原、血凝素以及热不稳定（56℃）和热稳定（100℃）毒素无疑与百日咳的免疫和/或毒性反应相关。看来，针对该疾病的第一道防线是防止细菌附着于呼吸道上皮纤毛的抗体，而第二道防线是针对百日咳毒素（HSF - LPF - IAP）的抗毒素。
