新型免疫调节剂贝抑素对人淋巴细胞体外及体内Ig分泌的影响。
Influence of Bestatin, a new immunomodulator, on Ig secretion by human lymphocytes in vitro and in vivo.
作者信息
Blomgren H, Forsgren M, Norberg R, von Stedingk L V, Wasserman J
出版信息
Int Arch Allergy Appl Immunol. 1981;64(3):338-44. doi: 10.1159/000232712.
Bestatin, a chemically well-defined immunomodulator, was tested for its capacity to interfere with PWM-induced Ig synthesis of peripheral lymphocytes from healthy donors. It was observed that secretion of IgA, IgG and IgM was impaired when Bestatin was present in the cultures. Serum Ig concentrations and antibody activities of IgG class to cytomegalovirus, herpes simplex and morbilli virus were examined in cancer patients who were treated with 30 mg of Bestatin daily for 1-21 weeks. These values remained constant during Bestatin treatment indicating that antibody secretion in vivo was not affected.
贝司他汀是一种化学结构明确的免疫调节剂，对其干扰健康供体外周淋巴细胞中PWM诱导的Ig合成的能力进行了测试。观察到当培养物中存在贝司他汀时，IgA、IgG和IgM的分泌受到损害。对每天接受30毫克贝司他汀治疗1至21周的癌症患者的血清Ig浓度和针对巨细胞病毒、单纯疱疹病毒和风疹病毒的IgG类抗体活性进行了检测。在贝司他汀治疗期间，这些值保持恒定，表明体内抗体分泌未受影响。
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