荚膜组织胞浆菌的温度和环核苷酸诱导的相变
Temperature- and cyclic nucleotide-induced phase transitions of Histoplasma capsulatum.
作者信息
Sacco M, Maresca B, Kumar B V, Kobayashi G S, Medoff G
出版信息
J Bacteriol. 1981 Apr;146(1):117-20. doi: 10.1128/jb.146.1.117-120.1981.
Abstract
The transition from yeast to mycelia of Histoplasma capsulatum could be accomplished by shifting the temperature of incubation from 37 to 25 degrees C. It was accompanied by many changes in cellular metabolism, including changes in respiration, intracellular cyclic adenosine 3',5'-monophosphate (cAMP) levels, and activities of two enzymes specific for the yeast phase, cystine reductase (EC 1.6.4.1) and cysteine oxidase (EC 1.13.11.20). Even at 37 degrees C, the yeast to mycelial transition could be induced by cAMP and agents which raise the intracellular levels of cAMP (theophylline, acetylsalicylic acid, prostaglandin E1, and nerve growth factor). During this morphogenesis the same pattern of changes occurred as in the temperature-induced transition. Therefore, these changes were not simply dependent on a shift in temperature, but rather were part of the process of the phase transition.
摘要
荚膜组织胞浆菌从酵母型向菌丝型的转变可通过将培养温度从37℃转变为25℃来实现。这伴随着细胞代谢的许多变化，包括呼吸作用、细胞内3',5'-环磷酸腺苷（cAMP）水平以及酵母期特异性的两种酶——胱氨酸还原酶（EC 1.6.4.1）和半胱氨酸氧化酶（EC 1.13.11.20）活性的变化。即使在37℃，cAMP以及能提高细胞内cAMP水平的物质（茶碱、乙酰水杨酸、前列腺素E1和神经生长因子）也能诱导酵母向菌丝的转变。在这种形态发生过程中，发生的变化模式与温度诱导的转变相同。因此，这些变化并非仅仅依赖于温度的改变，而是相变过程的一部分。
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