Robinson J S, Hart I C, Kingston E J, Jones C T, Thorburn G D
J Dev Physiol. 1980 Aug;2(4):239-48.
Intrauterine growth retardation was induced in sheep by removal of endometrial caruncles before pregnancy. At a second operation catheters were implanted into the ewe and fetus at 105-135 days of pregnancy. Three groups of fetuses: low birthweight-for-dates (small caruncle) normal birthweight-for dates (normal sized caruncle) and controls have been compared. The concentration of ACTH (60 +/- 6.9 pg/ml) in the normal-sized caruncle fetuses were lower in the controls (144 +/- 4.7 pg/ml) or small caruncle fetuses (142 +/- 53 pg/ml). Basal cortisol concentrations were similar in the controls (7.3 +/- 1.2 ng/ml) and normal-sized caruncle fetuses (6.5 +/- 0.5 ng/ml) but those in the small caruncle fetuses were significantly higher (12.7 +/- 1.0 ng/ml, P less than 0.001). The concentration of insulin correlated with plasma glucose and the mean concentrations were 19.2 +/- 1.6 mu units/ml (controls), 8.4 +/- 2.6 mu units/ml (normal-sized caruncle) and 3.9 +/- 1.6 mu units/ml (controls), 8.4 +/- 2.6 mu units/ml (normal-sized caruncle) and 3.9 +/- 1.6 mu units/ml (small caruncle). Prolactin was significantly lower in the small caruncle fetuses (2.1 +/- 0.3 ng/ml) compared to the controls (66.6 19.4 ng/ml) or normal-sized caruncles (76.1 +/- 38 ng/ml) but growth hormone concentrations in the small caruncle.
在怀孕前切除子宫内膜肉阜，从而在绵羊中诱导出子宫内生长迟缓。在第二次手术时，于怀孕105 - 135天向母羊和胎儿植入导管。对三组胎儿进行了比较：孕周别低出生体重儿（小肉阜）、孕周别正常出生体重儿（正常大小肉阜）和对照组。正常大小肉阜胎儿的促肾上腺皮质激素浓度（60±6.9皮克/毫升）低于对照组（144±4.7皮克/毫升）或小肉阜胎儿（142±53皮克/毫升）。对照组（7.3±1.2纳克/毫升）和正常大小肉阜胎儿（6.5±0.5纳克/毫升）的基础皮质醇浓度相似，但小肉阜胎儿的基础皮质醇浓度显著更高（12.7±1.0纳克/毫升，P<0.001）。胰岛素浓度与血糖相关，平均浓度分别为19.2±1.6微单位/毫升（对照组）、8.4±2.6微单位/毫升（正常大小肉阜）和3.9±1.6微单位/毫升（小肉阜）。与对照组（66.6±19.4纳克/毫升）或正常大小肉阜（76.1±38纳克/毫升）相比，小肉阜胎儿的催乳素显著更低（2.1±0.3纳克/毫升），但小肉阜胎儿的生长激素浓度……（原文此处不完整）
