Feasby T E, Bostock H, Sears T A
J Neurol Sci. 1981 Mar;49(3):439-54. doi: 10.1016/0022-510x(81)90033-2.
Rat dorsal roots were crushed and recordings of compound action potentials and single fibre longitudinal currents were made 12-85 days later from the regenerating portions. Maximum conduction velocities rose from 1.3 m/s at day 10 to 25.7 m/s by day 41 and single fibre velocities varied from 1.2 m/s at 12 days postcrush to 23.8 m/s at 85 days. Many fibres appeared to conduct continuously in the early stages, although the resolution of the technique was insufficient to exclude saltatory conduction over short internodes. Two fibres showed internodes of about 200 microns at 9 and 13 days of regeneration, suggesting that "nodal" regions may be formed before significant myelination. At 27 days post-crush and later, internodes were 300-425 microns in length. Many regenerating fibres had branches, both retrograde and orthograde. Reduced conduction velocities in rostral portions of regenerating fibres suggested tapering.
将大鼠背根神经节切断，12至85天后从再生部分记录复合动作电位和单纤维纵向电流。最大传导速度从第10天的1.3米/秒上升到第41天的25.7米/秒，单纤维速度从损伤后12天的1.2米/秒变化到85天的23.8米/秒。在早期阶段，许多纤维似乎能够持续传导，尽管该技术的分辨率不足以排除在短节间的跳跃式传导。两根纤维在再生9天和13天时显示节间长度约为200微米，这表明“节点”区域可能在显著髓鞘形成之前就已形成。在损伤后27天及之后，节间长度为300至425微米。许多再生纤维有逆行和顺行分支。再生纤维头端部分传导速度降低表明其逐渐变细。
