Driscoll S G
J Reprod Med. 1981 Apr;26(4):181-91.
The hydatidiform mole-gestational choriocarcinoma complex constitutes a graft qua tumor whose natural invasion, rejection and resolution share features of normal pregnancy and of neoplasms of other tissues. Trophoblastic neoplasms sometimes arise from morphogenetically abnormal chorions, notably the "partial mole," among others. Thus, they provide another demonstration of the association of teratogenic and carcinogenic events. Gestational choriocarcinoma is a complication of pregnancy, not a sequel to it. Although these tumors may arise from the trophoblast of any pregnancy, presenting symptoms during gestation or following it, they are much rarer than the innocuous conditions, normal and abnormal, with which they may be confused. A bone fide malignant neoplasm is less likely to be misdiagnosed as a banal phenomenon than is the reverse. Morphologically, the trophoblast is the key, and emphasis should be placed on its behavior. Taxonomy should follow suit, employing the simple, explicit terms chorioma and choriocarcinoma, graded to express the neoplastic attributes of the constituent epithelium.
葡萄胎 - 妊娠性绒毛膜癌复合体构成一种肿瘤性移植物，其天然的侵袭、排斥和消退兼具正常妊娠及其他组织肿瘤的特征。滋养层肿瘤有时起源于形态发生异常的绒毛膜，尤其是“部分性葡萄胎”等。因此，它们为致畸与致癌事件之间的关联提供了另一例证。妊娠性绒毛膜癌是妊娠的一种并发症，而非其后果。尽管这些肿瘤可源自任何妊娠的滋养层，在妊娠期或之后出现症状，但它们比可能与之混淆的正常及异常无害情况要罕见得多。真正的恶性肿瘤比反之更不容易被误诊为平凡现象。从形态学上看，滋养层是关键，应着重关注其行为表现。分类学也应如此，采用简单明确的术语“绒毛瘤”和“绒毛膜癌”，并分级以表达构成上皮的肿瘤属性。
