Cedgård S, Hallbäck D A, Jodal M, Lundgren O, Redfors S
Acta Physiol Scand. 1978 Feb;102(2):148-58. doi: 10.1111/j.1748-1716.1978.tb06058.x.
Blood flow distribution to the mucosa-submucosa and to the muscularis in the cat small intestine was investigated with a 85Kr elimination technique before and after exposing the intestinal mucosa for 30 min to cholera enterotoxin. In all experiments the toxin induced an intestinal secretion. Concomitantly, total intestinal blood flow was increased to a level 50 per cent above control 3 h after exposure. This vasodilatation reflected a doubling of mean blood flow in the mucosa--submucosa while muscularis blood flow remained unchanged. In another series of experiments the effect of cholera toxin on intestinal capillary hydraulic conductivity was investigated by determining the capillary filtration coefficient (CFC). A slight increase in CFC was noted during the 3 h observation period but this was not more pronounced than would have been expected from the concomitant vasodilatation. It is concluded that hemodynamic changes in the intestinal mucosa may be one of the several factors that probably are involved in the pathogenesis of cholera.
采用⁸⁵Kr清除技术，在猫小肠黏膜暴露于霍乱肠毒素30分钟前后，研究了黏膜下层和肌层的血流分布情况。在所有实验中，毒素均诱导了肠道分泌。与此同时，暴露3小时后，肠道总血流量增加至比对照水平高50%。这种血管舒张反映出黏膜下层平均血流量增加了一倍，而肌层血流量保持不变。在另一系列实验中，通过测定毛细血管滤过系数（CFC）来研究霍乱毒素对肠道毛细血管水力传导率的影响。在3小时的观察期内，CFC略有增加，但并不比伴随的血管舒张所预期的更明显。得出的结论是，肠道黏膜的血流动力学变化可能是霍乱发病机制中可能涉及的几个因素之一。
