Mishima H, Bausher L, Sears M, Gochu M, Ono H, Gregory D
Graefes Arch Clin Exp Ophthalmol. 1982;219(6):272-8. doi: 10.1007/BF00231412.
Delivery of 2 micrograms of cholera toxin (CT), a specific, irreversible activator of adenyl cyclase, via the blood causes dilation of capillaries and stromal edema of the ciliary processes. These morphologic changes occur within 3 h, are maximal at 12 to 24 h, then gradually return to normal by 72 h. In the late phase of hypotony, ultrastructural changes in the ciliary epithelia, similar to Greeff vesicles, are due to a "paracentesis effect" from hypotony, caused by decreased aqueous flow through the eye. Delivery of 2 micrograms of the B subunit of CT (Sub-B) causes very mild capillary dilation and stromal edema of ciliary processes. These changes reach their peak at 3 h, then return to normal at 24 h. No significant damage occurred to the pigmented or non-pigmented epithelium with either agent. No hemorrhage, invasion of inflammatory cells or appearance of fibrin exudates in the ciliary processes could be detected.
通过血液输送2微克霍乱毒素（CT），一种特异性、不可逆的腺苷酸环化酶激活剂，会导致毛细血管扩张和睫状体基质水肿。这些形态学变化在3小时内出现，在12至24小时达到最大值，然后在72小时逐渐恢复正常。在低眼压后期，睫状体上皮的超微结构变化类似于Greeff小泡，是由于眼内房水流量减少导致低眼压引起的“穿刺效应”。输送2微克CT的B亚基（Sub-B）会引起非常轻微的毛细血管扩张和睫状体基质水肿。这些变化在3小时达到峰值，然后在24小时恢复正常。两种药物对色素上皮或非色素上皮均未造成明显损伤。未检测到睫状体有出血、炎性细胞浸润或纤维蛋白渗出物出现。
