Morris J A, Aulisio C G, Hoffman J C, Young B G
Med Hypotheses. 1981 Mar;7(3):353-61. doi: 10.1016/0306-9877(81)90072-4.
Influenza, mumps and measles viruses were examined for their ability to induce in guinea pigs homologous and cross-reactive delayed hypersensitivity. A majority of the animals skin tested with homologous and a portion of the animals skin tested with heterologous viruses and vaccines developed positive reactions. Findings with the heterologous preparations suggest that the observed cross-reactive hypersensitivity might be due to shared antigens of viral or substrate origin in the influenza, mumps and measles preparations. The present findings in guinea pigs suggest that the adverse effects, attributed in whole or in part to induced hypersensitivity, observed in man following injection of killed influenza, mumps and measles vaccines could be due to cross-reactive delayed hypersensitivity resulting from the use of these preparations.
研究了流感病毒、腮腺炎病毒和麻疹病毒诱导豚鼠产生同源和交叉反应性迟发型超敏反应的能力。大多数用同源病毒进行皮肤试验的动物以及一部分用异源病毒和疫苗进行皮肤试验的动物出现了阳性反应。异源制剂的研究结果表明，观察到的交叉反应性超敏反应可能是由于流感、腮腺炎和麻疹制剂中病毒或底物来源的共同抗原所致。豚鼠的当前研究结果表明，人类在接种灭活流感、腮腺炎和麻疹疫苗后观察到的全部或部分归因于诱导超敏反应的不良反应，可能是由于使用这些制剂导致的交叉反应性迟发型超敏反应。
