Duka T, Schubert P, Wüster M, Stoiber R, Herz A
Neurosci Lett. 1981 Jan 20;21(2):119-24. doi: 10.1016/0304-3940(81)90368-2.
A differential localization of binding sites in the rat brain for [3H]D-Ala2,Leu5-enkephalin ([3H]DADL) and [3H]etorphine ([3H]Eto) was been demonstrated by an in vitro autoradiography technique. Labeling with [3H]DADL was found predominantly in septum and paraventricular nuclei of hypothalamus, whereas [3H]Eto labeling was primarily observed in the periaqueductal gray and several thalamic nuclei. The distinctive patterns of labeling by the two ligands in certain central nervous system structures suggests the existence of specific neuronal pathways which are preferentially labeled with either [3H]DADL or [3H]Eto.
通过体外放射自显影技术已证实，大鼠脑中[3H]D-Ala2，Leu5-脑啡肽（[3H]DADL）和[3H]埃托啡（[3H]Eto）结合位点的差异定位。发现[3H]DADL标记主要位于下丘脑的隔区和室旁核，而[3H]Eto标记主要见于导水管周围灰质和几个丘脑核。两种配体在某些中枢神经系统结构中的独特标记模式表明存在特定的神经元通路，这些通路优先被[3H]DADL或[3H]Eto标记。
