Kandeel F R, London D R, Butt W R, Davila N, Rudd B T, Sadeghian S, Lynch S S, Edwards R L, Horder M
Clin Endocrinol (Oxf). 1980 Dec;13(6):601-12. doi: 10.1111/j.1365-2265.1980.tb03429.x.
Fifteen patients with the polycystic ovarian (PCO) syndrome were classified into Group A (n = 6) and Group B (n = 9) based on their LH responses to LHRH before and at 44 and 92h after administration of oestradiol benzoate. Adrenal function in both groups was assessed by comparing the hormone responses to ACTH (0.5mg twice daily for 4 days) with those obtained in nine normally ovulating women during the early follicular phase of their cycles. In Group A patients there was no significant difference from normals in the serum concentration of dehydroepiandrosterone sulphate (DHAS), 17 alpha-hydroxy-progesterone (17-OHP) or androgens (testosterone and dihydrotestosterone). In contrast, the serum concentrations in Group B were significantly higher (P less than 0.01) for each of these steroids before ACTH, and remained higher at 2 and 4 days for DHAS, but not for the other two steroids. The concentration of oestrone was significantly higher (P less than 0.05) in Group B patients before, and 2 days after, ACTH, while in Group A patients higher concentrations (P less than 0.02) were found only after 2 days. The concentrations of oestradiol, on the other hand, were not different from normal in either group before ACTH and became lower than normal in both groups at 2 days and remained lower at 4 days in Group B. The concentration of cortisol was within the normal range throughout in Group A, but was lower than normal after 4 days in Group B patients (P less than 0.05). The ratios between the sums of concentrations of DHAS to cortisol on days 2 and 4 (P less than 0.001) or 17-OHP to cortisol (P less than 0.05) were elevated in Group B compared with normal subjects. LH, FSH and prolactin values were normal throughout in Group A, but in Group B patients the mean value for LH was significantly elevated before ACTH and at 4 days after ACTH (P less than 0.02).
15例多囊卵巢（PCO）综合征患者根据其在苯甲酸雌二醇给药前、给药后44小时和92小时对促黄体生成素释放激素（LHRH）的反应被分为A组（n = 6）和B组（n = 9）。通过比较两组对促肾上腺皮质激素（每天两次，每次0.5mg，共4天）的激素反应与9名正常排卵女性在其月经周期卵泡早期获得的反应，评估两组的肾上腺功能。A组患者硫酸脱氢表雄酮（DHAS）、17α-羟孕酮（17-OHP）或雄激素（睾酮和双氢睾酮）的血清浓度与正常人相比无显著差异。相比之下，B组患者在促肾上腺皮质激素给药前，这些类固醇的血清浓度均显著更高（P < 0.01），且DHAS在给药后2天和4天仍保持较高水平，但其他两种类固醇并非如此。B组患者在促肾上腺皮质激素给药前和给药后2天，雌酮浓度显著更高（P < 0.05），而A组患者仅在给药后2天发现更高浓度（P < 0.02）。另一方面，两组在促肾上腺皮质激素给药前雌二醇浓度与正常无异，且两组在给药后2天均低于正常水平，B组在给药后4天仍保持较低水平。A组患者皮质醇浓度始终在正常范围内，但B组患者在给药后4天低于正常水平（P < 0.05）。与正常受试者相比，B组在给药后2天和4天DHAS与皮质醇浓度之和的比值（P < 0.001）或17-OHP与皮质醇的比值（P < 0.05）升高。A组患者促黄体生成素（LH）、促卵泡生成素（FSH）和催乳素值始终正常，但B组患者在促肾上腺皮质激素给药前和给药后4天LH平均值显著升高（P < 0.02）。
