Carmina E, Rosato F, Maggiore M, Gagliano A M, Indovina D, Jannì A
Acta Endocrinol (Copenh). 1984 Jan;105(1):99-104. doi: 10.1530/acta.0.1050099.
To evaluate the prevalence of hyperprolactinaemia in PCO patients and its possible correlation with a steroid pattern, we studied prolactin secretion (basal and after TRH stimulation) in 40 women affected by typical PCO. LH, FSH, testosterone, oestradiol, oestrone, DHEA-s and 17-OHP serum levels were also evaluated. Twenty-one patients had prolactin (Prl) values in the normal range both in baseline conditions and after TRH stimulation; 10 patients had normal basal values of Prl but an exaggerated response to TRH stimulation; 9 patients had high Prl basal values and an exaggerated response to TRH. The presence of hyperprolactinaemia was associated with increased serum levels of oestrone (P less than 0.01), DHEA-s (P less than 0.01) and 17-OHP (P less than 0.05). In conclusion, hyperprolactinaemia is as relatively frequent condition which affects almost half the patients suffering from PCO and is probably related to an increase of serum oestrogens, mostly oestrone. Moreover, in patients with PCO and hyperprolactinaemia, the production of some other steroids is also affected.
为评估多囊卵巢（PCO）患者高泌乳素血症的患病率及其与类固醇模式的可能相关性，我们研究了40例典型PCO女性的泌乳素分泌情况（基础状态及促甲状腺激素释放激素[TRH]刺激后）。同时还评估了促黄体生成素（LH）、促卵泡生成素（FSH）、睾酮、雌二醇、雌酮、硫酸脱氢表雄酮（DHEA-s）和17-羟孕酮（17-OHP）的血清水平。21例患者在基线状态及TRH刺激后泌乳素（Prl）值均在正常范围内；10例患者Prl基础值正常，但对TRH刺激反应过度；9例患者Prl基础值较高且对TRH刺激反应过度。高泌乳素血症的存在与雌酮（P<0.01）、DHEA-s（P<0.01）和17-OHP（P<0.05）血清水平升高相关。总之，高泌乳素血症是一种相对常见的情况，影响了近一半的PCO患者，可能与血清雌激素尤其是雌酮水平升高有关。此外，在PCO和高泌乳素血症患者中，其他一些类固醇的产生也受到影响。
