大鼠中灭活脊髓灰质炎疫苗的效力测试。
Potency testing of killed polio vaccine in rats.
作者信息
van Steenis G, van Wezel A L, Sekhuis V M
出版信息
Dev Biol Stand. 1981;47:119-28.
PMID:6262142
Abstract
Various laboratory animal species were considered for testing the potency of killed poliovaccine. The rat appeared most suitable for obtaining quantitative information by measuring the titre of the antibody response. There was, in general, a good correlation between antibody response in rats and D-antigen titre. This relationship appeared less clear for heat-degraded or long-stored vaccines.
摘要
为了测试灭活脊髓灰质炎疫苗的效力，人们考虑了多种实验动物物种。大鼠似乎最适合通过测量抗体反应滴度来获取定量信息。一般来说，大鼠的抗体反应与D抗原滴度之间存在良好的相关性。对于热降解或长期储存的疫苗，这种关系似乎不太明显。
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