Yadin E, Thomas E
J Comp Physiol Psychol. 1981 Apr;95(2):331-40. doi: 10.1037/h0077769.
Multiple-unit activity was recorded in the lateral septum of rats during Pavlovian differential conditioning. In Experiment 1, one group of animals received a classical aversive discrimination paradigm, while another group was presented with a control procedure in which the unconditioned stimuli (shocks) were administered randomly with regard to the conditioned stimuli. Septal unit activity increased during presentations of the conditioned inhibitor and was markedly suppressed during presentations of the conditioned excitor in the conditioning-group animals and not in the control animals. Baseline activity remained unchanged in the conditioning group but was suppressed in the random control group. Furthermore, termination of the aversive stimuli was marked by a burst of firing in the conditioning group, but no such rebound was seen in the control group. In Experiment 2, a classical appetitive discrimination paradigm was given, in which septal unit activity was found to increase in the presence of the conditioned excitor and was suppressed in the presence of the conditioned inhibitor. The results are interpreted as indicating a role for the septum in the relief of aversive states.
在巴甫洛夫式差异条件反射过程中，记录了大鼠外侧隔区的多单位活动。在实验1中，一组动物接受经典厌恶性辨别范式，而另一组则接受一种对照程序，其中无条件刺激（电击）相对于条件刺激随机施加。在条件抑制物呈现期间，隔区单位活动增加，而在条件性兴奋物呈现期间，条件反射组动物的活动明显受到抑制，而对照组动物则没有。条件反射组的基线活动保持不变，但随机对照组的基线活动受到抑制。此外，厌恶性刺激的终止在条件反射组中以一阵放电为标志，但在对照组中未观察到这种反弹。在实验2中，给予经典的食欲性辨别范式，其中发现隔区单位活动在条件性兴奋物出现时增加，而在条件性抑制物出现时受到抑制。结果被解释为表明隔区在缓解厌恶状态中起作用。
