Smith-Barbaro P A, Hanson D, Reddy B S
J Nutr. 1981 May;111(5):789-97. doi: 10.1093/jn/111.5.789.
The effect of dietary wheat bran and citrus pulp on hepatic, small intestinal and colonic HMG-CoA reductase activity, cytochrome P450 and cytochrome b5 levels was studied in F344 rats. Colonic and small intestinal HMG-CoA reductase activity was significantly lower in the wheat bran group than the control group. No differences in hepatic HMG-CoA reductase activity occurred between the wheat bran, citrus pulp and control groups. A direct relationship between hepatic cholesterol levels and hepatic Cytochrome P450 levels was demonstrated. A similar trend was exhibited between fecal cholesterol and colonic cytochrome P450 levels in the colon. These results suggest that the effect of certain types of dietary fiber in small intestinal and colonic cholesterogenesis is mediated through alterations in small intestinal and colonic mixed function oxidase activity.
在F344大鼠中研究了日粮麦麸和柑橘果肉对肝脏、小肠和结肠HMG-CoA还原酶活性、细胞色素P450和细胞色素b5水平的影响。麦麸组的结肠和小肠HMG-CoA还原酶活性显著低于对照组。麦麸组、柑橘果肉组和对照组之间肝脏HMG-CoA还原酶活性没有差异。肝脏胆固醇水平与肝脏细胞色素P450水平之间存在直接关系。结肠中粪便胆固醇与结肠细胞色素P450水平之间也呈现出类似趋势。这些结果表明，某些类型的膳食纤维对小肠和结肠胆固醇生成的影响是通过改变小肠和结肠混合功能氧化酶活性来介导的。
