Reddy B S, Mori H, Nicolais M
J Natl Cancer Inst. 1981 Mar;66(3):553-7.
The effect of dietary wheat bran and dehydrated citrus fiber on carcinogenesis of the colon and small intestine was studied in male F344 rats. Weanling rats were fed semi-purified diets containing 5% fat and 15% wheat bran or citrus fiber. At 7 weeks of age, all animals, except vehicle-treated controls, received weekly sc injections of 8 mg azoxymethane (AOM)/kg body weight for 10 weeks. The AOM- or vehicle-treated groups were autopsied 20 weeks after the last injection of AOM. The animals fed the wheat bran or citrus fiber diet and treated with AOM had a lower incidence (number of animals with tumors) and multiplicity (number of tumors/tumor-bearing animal) of colon tumors and tumors of the small intestine than did those fed the control diet and treated with AOM. Animals fed the diet containing wheat bran developed fewer adenomas and adenocarcinomas of the colon than did the rats fed the control diet; the number of adenomas but not the number of adenocarcinomas was reduced in rats fed the citrus pulp diet. This study thus indicates that diets containing wheat bran and citrus fiber reduced the risk of intestinal cancer.
在雄性F344大鼠中研究了膳食麦麸和脱水柑橘纤维对结肠和小肠致癌作用的影响。将断乳大鼠喂食含5%脂肪和15%麦麸或柑橘纤维的半纯化日粮。7周龄时，除溶剂处理的对照组外，所有动物每周皮下注射8mg/kg体重的偶氮甲烷（AOM），持续10周。在最后一次注射AOM后20周对AOM处理组或溶剂处理组动物进行尸检。与喂食对照日粮并接受AOM处理的动物相比，喂食麦麸或柑橘纤维日粮并接受AOM处理的动物结肠肿瘤和小肠肿瘤的发生率（患肿瘤动物数量）和多发性（肿瘤数量/患肿瘤动物）较低。喂食含麦麸日粮的动物结肠腺瘤和腺癌的发生数量少于喂食对照日粮的大鼠；喂食柑橘果肉日粮的大鼠腺瘤数量减少，但腺癌数量未减少。因此，本研究表明含麦麸和柑橘纤维的日粮降低了患肠癌的风险。
