Spahr J, Demers L M, Shochat S J
J Pediatr Surg. 1981 Feb;16(1):32-4. doi: 10.1016/s0022-3468(81)80111-x.
A 4-yr-old boy with Wilms' tumor, hypertension, and hyperreninemia is presented. Three times as much renin was extracted from tumor tissue as from adjacent renal parenchyma, suggesting that the tumor itself was the primary source of the renin and cause of the hypertension. Other reported cases of hypertension and increased renin production with Wilms' tumor are reviewed. Hypertension is a very frequent finding in patients presenting with Wilms' tumor. The possibility that many of these neoplasms may be found to hypersecrete renin if properly investigated is discussed.
本文报告了一名患有肾母细胞瘤、高血压和高肾素血症的4岁男孩。从肿瘤组织中提取的肾素是相邻肾实质的三倍，这表明肿瘤本身是肾素的主要来源和高血压的病因。本文还回顾了其他报道的肾母细胞瘤伴高血压和肾素分泌增加的病例。高血压在肾母细胞瘤患者中是非常常见的表现。文中讨论了如果进行适当调查，许多这些肿瘤可能被发现过度分泌肾素的可能性。
