吗啡拮抗剂与 consummatory 行为。（注：consummatory 在这里可译为“完成性的”“终结性的”等，但不太明确其在该医学语境下的准确对应，需要结合更具体内容理解，一般在医学行为学等领域会有特定含义。）

Morphine antagonists and consummatory behaviors.

作者信息

Ostrowski N L, Rowland N, Foley T L, Nelson J L, Reid L D

出版信息

Pharmacol Biochem Behav. 1981 Apr;14(4):549-59. doi: 10.1016/0091-3057(81)90316-6.

Abstract

Opiate antagonists were tested for their effects upon either drinking or eating in eight experiments. Naloxone, nalorphine, and the active isomer of WIN 44,441 all reduce drinking. Neither an analog of nalorphine that does not cross the blood-brain barrier, nor the inactive isomer of WIN 44,441 is effective in reducing water intake. These data provide support for the conclusion that these antagonists ahve stereospecific effects within the central nervous system. Naloxone suppresses drinking following procedures inducing osmotic, volemic, or hormonal thirst. Naloxone suppresses eating following procedures inducing glucoprivation but does not alter eating elicited by tail-pressure. Collectively, these data lead to the conclusion that endorphins play a role in the organization of ingestive behavior following challenges to homeostasis.

摘要

在八项实验中测试了阿片类拮抗剂对饮水或进食的影响。纳洛酮、烯丙吗啡和WIN 44,441的活性异构体均能减少饮水。既不能穿过血脑屏障的烯丙吗啡类似物，也不是WIN 44,441的无活性异构体，在减少水摄入量方面均无效。这些数据支持了以下结论：这些拮抗剂在中枢神经系统内具有立体特异性作用。纳洛酮在诱导渗透性、容量性或激素性口渴的程序后抑制饮水。纳洛酮在诱导糖剥夺的程序后抑制进食，但不改变尾部压迫引起的进食。总体而言，这些数据得出结论，内啡肽在体内平衡受到挑战后的摄食行为组织中起作用。