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惰性气体在生物流体和组织中的溶解度:综述

Solubility of inert gases in biological fluids and tissues: a review.

作者信息

Weathersby P K, Homer L D

出版信息

Undersea Biomed Res. 1980 Dec;7(4):277-96.

PMID:6262972
Abstract

Data have been tabulated from more than 150 references on the solubility of inert gases in fluids and tissues of biological interest. Thirty-two gases have been studied in blood with measured solubility ranging from 0.005 to 16 ml of gas at 37 degrees C per ml of blood per ATA (Ostwald coefficient). For most gases, solubility in other tissues such as muscle or brain is between 60% and 300% of blood solubility. Measured solubilities in biological tissues do not correspond well to solubility in water and oil. Most gases decrease in solubility by 1%-6% for each degree C rise in temperature. The effect of pressure on solubility has not been well studied, and only crude estimates can be obtained by using methods of chemical thermodynamics.

摘要

已从150多篇关于惰性气体在具有生物学意义的流体和组织中的溶解度的参考文献中整理出数据。已对32种气体在血液中的溶解度进行了研究,在37摄氏度、每ATA(奥斯特瓦尔德系数)下,每毫升血液中气体的测量溶解度范围为0.005至16毫升。对于大多数气体,在其他组织如肌肉或大脑中的溶解度是血液溶解度的60%至300%。在生物组织中测得的溶解度与在水和油中的溶解度不太相符。大多数气体温度每升高1摄氏度,溶解度降低1%至6%。压力对溶解度的影响尚未得到充分研究,只能通过化学热力学方法获得粗略估计值。

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