黄曲霉毒素B1及其共轭代谢产物在大鼠胃肠道微生物群中的生物转化。
Biotransformation of aflatoxin B1 and its conjugated metabolites by rat gastrointestinal microfloras.
作者信息
Wei C, Macy J M, Hsieh D P
出版信息
Appl Environ Microbiol. 1981 Feb;41(2):549-51. doi: 10.1128/aem.41.2.549-551.1981.
Abstract
Rat cecal microflora from high- and low-fiber-fed animals hydrolyzed aflatoxin conjugates to metabolites indistinguishable from aflatoxin B1 and aflatoxin P1, but aflatoxicol was not a transformation product.
摘要
来自高纤维和低纤维喂养动物的大鼠盲肠微生物群将黄曲霉毒素共轭物水解为与黄曲霉毒素B1和黄曲霉毒素P1无法区分的代谢物，但黄曲霉毒素醇不是转化产物。
相似文献
1
Biotransformation of aflatoxin B1 and its conjugated metabolites by rat gastrointestinal microfloras.黄曲霉毒素B1及其共轭代谢产物在大鼠胃肠道微生物群中的生物转化。
Appl Environ Microbiol. 1981 Feb;41(2):549-51. doi: 10.1128/aem.41.2.549-551.1981.
2
Aflatoxicol: major aflatoxin B1 metabolite in rat plasma.黄曲霉毒素醇：大鼠血浆中主要的黄曲霉毒素B1代谢产物。
Science. 1978 Apr 21;200(4339):325-7. doi: 10.1126/science.635590.
3
Metabolite distribution and rate of residue clearance in turkeys fed a diet containing aflatoxin B1.饲喂含黄曲霉毒素B1日粮的火鸡体内代谢物分布及残留清除率
Food Chem Toxicol. 1983 Aug;21(4):463-7. doi: 10.1016/0278-6915(83)90103-5.
4
Aflatoxicol and aflatoxins B1 and M1 in the tissues of pigs receiving aflatoxin.接受黄曲霉毒素的猪组织中的黄曲霉毒素醇以及黄曲霉毒素B1和M1
J Assoc Off Anal Chem. 1982 Jul;65(4):884-7.
5
Urinary excretion of thiol conjugates of aflatoxin B1 in rats and hamsters.黄曲霉毒素B1硫醇共轭物在大鼠和仓鼠体内的尿排泄情况。
Cancer Lett. 1984 Mar;22(2):125-33. doi: 10.1016/0304-3835(84)90109-5.
6
Activation and deactivation of aflatoxin B1 in isolated rat hepatocytes.
Biochem Biophys Res Commun. 1983 Jan 27;110(2):668-74. doi: 10.1016/0006-291x(83)91201-9.
7
8
Molecular dosimetry in rat urine of aflatoxin-N7-guanine and other aflatoxin metabolites by multiple monoclonal antibody affinity chromatography and immunoaffinity/high performance liquid chromatography.采用多种单克隆抗体亲和色谱法及免疫亲和/高效液相色谱法对大鼠尿液中黄曲霉毒素-N7-鸟嘌呤及其他黄曲霉毒素代谢产物进行分子剂量测定。
Cancer Res. 1992 Jan 15;52(2):267-74.
9
Metabolism of aflatoxin B1 in the isolated nuclei of rat liver.黄曲霉毒素B1在大鼠肝脏离体细胞核中的代谢
J Biochem. 1981 Feb;89(2):443-52. doi: 10.1093/oxfordjournals.jbchem.a133219.
10
Glucuronides in bile of rainbow trout (Salmo gairdneri) injected with [3H]aflatoxin B1 and the effects of dietary beta-naphthoflavone.注射[3H]黄曲霉毒素B1的虹鳟鱼（Salmo gairdneri）胆汁中的葡糖醛酸苷及膳食β-萘黄酮的影响。
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;78(1):13-9. doi: 10.1016/0742-8413(84)90040-9.
引用本文的文献
1
Bioactivation of cysteine conjugates of 1-nitropyrene oxides by cysteine conjugate beta-lyase purified from Peptostreptococcus magnus.从巨大消化链球菌中纯化的半胱氨酸共轭β-裂解酶对1-硝基芘氧化物的半胱氨酸共轭物的生物活化作用。
Appl Environ Microbiol. 1995 Nov;61(11):3781-7. doi: 10.1128/aem.61.11.3781-3787.1995.
本文引用的文献
1
Transformation of aflatoxin B1 by steroid-hydroxylating fungi.黄曲霉毒素B1被甾体羟基化真菌转化。
Can J Microbiol. 1969 Jun;15(6):495-500. doi: 10.1139/m69-086.
2
Epidemiology of cancer of the colon and rectum.结肠直肠癌的流行病学
Cancer. 1971 Jul;28(1):3-13. doi: 10.1002/1097-0142(197107)28:1<3::aid-cncr2820280104>3.0.co;2-n.
3
Conversion of aflatoxin B 1 to isomeric hydroxy compounds by Rhizopus spp.
J Agric Food Chem. 1972 Nov-Dec;20(6):1100-2. doi: 10.1021/jf60184a040.
4
Use of monkey liver microsomes in production of aflatoxin Q1.猴肝微粒体在黄曲霉毒素Q1生产中的应用。
J Agric Food Chem. 1974 May-Jun;22(3):515-7. doi: 10.1021/jf60193a048.
5
Toxicologic implications of biotransformation by intestinal microflora.肠道微生物群生物转化的毒理学意义。
Toxicol Appl Pharmacol. 1972 Dec;23(4):769-81. doi: 10.1016/0041-008x(72)90118-4.
6
Metabolism of foreign compounds by gastrointestinal microorganisms.胃肠道微生物对外源化合物的代谢。
Pharmacol Rev. 1973 Dec;25(4):451-523.
7
Preparation of labeled aflatoxins with high specific activities.高比活度标记黄曲霉毒素的制备。
Appl Microbiol. 1971 Jul;22(1):79-83. doi: 10.1128/am.22.1.79-83.1971.
8
Aflatoxicol: structure of a new transformation product of aflatoxin B 1.黄曲霉毒素醇：黄曲霉毒素B1一种新转化产物的结构。
Can J Biochem. 1970 Jul;48(7):830-2. doi: 10.1139/o70-130.
9
High-pressure liquid chromatography of oxidative aflatoxin metabolites.氧化型黄曲霉毒素代谢产物的高压液相色谱分析
J Chromatogr. 1976 Feb 18;117(2):474-9. doi: 10.1016/0021-9673(76)80031-3.
10
Microbial models of mammalian metabolism.
J Pharm Sci. 1975 Nov;64(11):1737-59. doi: 10.1002/jps.2600641104.
Zotero 插件