白色脂肪细胞中α-肾上腺素能受体的个体发生发育及反应性
Ontogenic development of alpha-adrenergic receptors and responsiveness in white adipocytes.
作者信息
Pecquery R, Giudicelli Y
出版信息
Biochem J. 1980 Dec 15;192(3):947-50. doi: 10.1042/bj1920947.
Abstract
The influence of age on adipocyte alpha-adrenergic receptors was studied by using the binding of [3H]dihydroergocryptine to crude adipocyte membranes from hamsters of different ages (1-10 months). The number of alpha-receptor sites was found to increase with increasing age, but in contrast, their binding affinity remained unchanged. These changes in receptor concentrations, which were not related to cell-size differences, were also accompanied by parallel variations of the alpha-adrenergic responsiveness of the fat-cells.
摘要
通过利用[3H]二氢麦角隐亭与不同年龄（1 - 10个月）仓鼠的粗脂肪细胞膜结合，研究了年龄对脂肪细胞α - 肾上腺素能受体的影响。发现α - 受体位点的数量随年龄增长而增加，但相比之下，它们的结合亲和力保持不变。这些受体浓度的变化与细胞大小差异无关，同时脂肪细胞的α - 肾上腺素能反应性也出现了相应的变化。
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2
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