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实验性犬腺病毒肾小球肾炎：口服攻击后肾小球病变的持续存在

Experimental canine adenovirus glomerulonephritis: persistence of glomerular lesions after oral challenge.

作者信息

Wright N G, Nash A S, Cornwell H J

出版信息

Br J Exp Pathol. 1981 Apr;62(2):183-9.

PMID:6263307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2041659/
Abstract

Ten dogs were given canine adenovirus by the non-lethal oral route. Eight dogs were biopsied at 10 days after administration of virus in order to establish the presence of immune-complex glomerulonephritis. At this time, granular deposits of IgG, IgM, C3 and viral antigen were observed in a mesangial location and electrondense deposits were found. The dogs were then killed up to 40 days after receiving virus and, in all cases, deposits of immunoglobulins and complement together with the mesangial proliferative lesions were found to have persisted.

摘要

十只狗通过非致死性口服途径感染犬腺病毒。八只狗在接种病毒后10天进行活检，以确定免疫复合物性肾小球肾炎的存在。此时，在系膜部位观察到IgG、IgM、C3和病毒抗原的颗粒状沉积物，并发现了电子致密沉积物。这些狗在接受病毒后长达40天被处死，在所有病例中，均发现免疫球蛋白和补体沉积物以及系膜增殖性病变持续存在。

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Experimental canine adenovirus glomerulonephritis: persistence of glomerular lesions after oral challenge.实验性犬腺病毒肾小球肾炎：口服攻击后肾小球病变的持续存在
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引用本文的文献

1
Experimental canine adenovirus glomerulonephritis: histological, immunofluorescence and ultrastructural features of the early glomerular changes.实验性犬腺病毒肾小球肾炎：早期肾小球病变的组织学、免疫荧光及超微结构特征
Br J Exp Pathol. 1983 Jun;64(3):312-9.

本文引用的文献

1
Persistence of virus in urine as factor in spread of infectious hepatitis in dogs.病毒在尿液中的持续存在作为犬传染性肝炎传播的一个因素。
Proc Soc Exp Biol Med. 1951 Jun;77(2):279-81. doi: 10.3181/00379727-77-18749.
2
Mesangial localization of immune complexes in experimental canine adenovirus glomerulonephritis.实验性犬腺病毒肾小球肾炎中免疫复合物的系膜定位。
Br J Exp Pathol. 1974 Oct;55(5):458-65.
3
Canine adenovirus nephritis.犬腺病毒肾炎
J Small Anim Pract. 1971 Dec;12(12):657-64. doi: 10.1111/j.1748-5827.1971.tb06193.x.
4
Chronic renal failure in dogs: a comparative clinical and morphological study of chronic glomerulonephritis and chronic interstitial nephritis.犬慢性肾衰竭：慢性肾小球肾炎与慢性间质性肾炎的比较临床与形态学研究
Vet Rec. 1976 Apr 10;98(15):288-93. doi: 10.1136/vr.98.15.288.
5
An immunopathologic study of interstitial nephritis associated with experimental canine adenovirus infection.实验性犬腺病毒感染相关间质性肾炎的免疫病理学研究
J Pathol. 1976 Dec;120(4):221-8. doi: 10.1002/path.1711200405.
6
Detection of immune complexes in the serum of dogs infected with canine adenovirus.感染犬腺病毒的犬血清中免疫复合物的检测
Res Vet Sci. 1976 Jul;21(1):119-21.