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感染犬腺病毒的犬血清中免疫复合物的检测

Detection of immune complexes in the serum of dogs infected with canine adenovirus.

作者信息

Morrison W I, Wright N G

出版信息

Res Vet Sci. 1976 Jul;21(1):119-21.

PMID:181806
Abstract

Evidence for the presence of circulating virus-immune complexes in dogs experimentally infected with canine adenovirus was found when deposits of canine IgG were present in the glomeruli of recipient mice. This passive transfer of complexes occurred only with serum taken at the height of the disease when antibody titres were low and when deposition of complexes in the donor dogs was maximal. Transfer of complexes was not obtained early in the disease (no circulating antibody and minimal deposition of complexes) nor later in the disease (high circulating antibody and minimal complex deposition).

摘要

当在受体小鼠的肾小球中发现犬IgG沉积时,就找到了实验感染犬腺病毒的犬体内存在循环病毒免疫复合物的证据。这种复合物的被动转移仅发生在疾病高峰期采集的血清中,此时抗体滴度较低,且供体犬体内复合物的沉积量最大。在疾病早期(无循环抗体且复合物沉积极少)或疾病后期(循环抗体高且复合物沉积极少)均未获得复合物的转移。

相似文献

1
Detection of immune complexes in the serum of dogs infected with canine adenovirus.感染犬腺病毒的犬血清中免疫复合物的检测
Res Vet Sci. 1976 Jul;21(1):119-21.
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引用本文的文献

1
Experimental canine adenovirus glomerulonephritis: persistence of glomerular lesions after oral challenge.实验性犬腺病毒肾小球肾炎:口服攻击后肾小球病变的持续存在
Br J Exp Pathol. 1981 Apr;62(2):183-9.
2
Determination of immune complexes in sera from dogs with various diseases by mastocytoma cell assay.用肥大细胞瘤细胞试验测定患有各种疾病的犬血清中的免疫复合物。
J Clin Microbiol. 1982 Jan;15(1):64-8. doi: 10.1128/jcm.15.1.64-68.1982.