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胰高血糖素、肾上腺素以及α和β肾上腺素能药物对离体兔肝细胞和灌注肝脏中糖原分解的影响。

The influences of glucagon, epinephrine and alpha- and beta-adrenergic agents on glycogenolysis in isolated rabbit hepatocytes and perfused livers.

作者信息

Rufo G A, Yorek M A, Ray P D

出版信息

Biochim Biophys Acta. 1981 May 18;674(3):297-305. doi: 10.1016/0304-4165(81)90360-3.

DOI:10.1016/0304-4165(81)90360-3
PMID:6263353
Abstract
  1. Glucagon, epinephrine, norepinephrine, dibutyryl cyclic AMP, isoproterenol and phenylephrine each enhance glycogenolysis in isolated perfused rabbit livers and/or hepatocytes. 2. Such enhancement by epinephrine, norepinephrine, isoproterenol and phenylephrine is eliminated by propranolol but unaltered by phentolamine, suggesting that stimulation of glycogenolysis by each of these agents involves beta-adrenergic-mediated mechanism(s). 3. Data obtained with hepatocytes from 16--20-week-old rabbits and from 7--8-week-old rabbits are identical as far as enhancement of glycogenolysis by beta-adrenergic stimulation is concerned, implying that the nature of functional adrenergic receptors in rabbit liver does not change during the process of maturation.
摘要
  1. 胰高血糖素、肾上腺素、去甲肾上腺素、二丁酰环磷腺苷、异丙肾上腺素和去氧肾上腺素均可增强离体灌注兔肝和/或肝细胞中的糖原分解作用。2. 肾上腺素、去甲肾上腺素、异丙肾上腺素和去氧肾上腺素所引起的这种增强作用可被普萘洛尔消除，但不受酚妥拉明影响，这表明这些药物中每一种对糖原分解的刺激都涉及β-肾上腺素能介导的机制。3. 就β-肾上腺素能刺激增强糖原分解作用而言，从16 - 20周龄兔和7 - 8周龄兔肝细胞获得的数据是相同的，这意味着兔肝中功能性肾上腺素能受体的性质在成熟过程中不会改变。

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引用本文的文献

1
Lack of V1 vasopressin receptors in rabbit hepatocytes.兔肝细胞中缺乏V1血管加压素受体。
Biochem J. 1989 Apr 15;259(2):609-11. doi: 10.1042/bj2590609.