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兔肝细胞中缺乏V1血管加压素受体。

Lack of V1 vasopressin receptors in rabbit hepatocytes.

作者信息

Vandekerckhove A, Miot F, Keppens S, De Wulf H

机构信息

Afedling Biochemie, Campus Gasthuisberg, Fakulteit Geneeskunde, Katholieke Universiteit Leuven, Belgium.

出版信息

Biochem J. 1989 Apr 15;259(2):609-11. doi: 10.1042/bj2590609.

DOI:10.1042/bj2590609
PMID:2524192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1138554/
Abstract

Vasopressin does not induce glycogenolysis in rabbit hepatocytes; glucagon, angiotensin, phenylephrine and ATP are as potent as with rat hepatocytes, whereas isoprenaline is nearly 10000 times more potent in the rabbit. Binding studies of [3H]vasopressin reveal the complete absence of specific vasopressin receptors on rabbit liver plasma membranes. We verified that vasopressin acts as an antidiuretic and vasopressor agent in the rabbit. We conclude that there is a selective lack of V1 vasopressin receptors in rabbit liver.

摘要

血管加压素不会诱导兔肝细胞发生糖原分解；胰高血糖素、血管紧张素、去氧肾上腺素和三磷酸腺苷（ATP）在兔肝细胞中的作用与在大鼠肝细胞中一样有效，而异丙肾上腺素在兔中的效力几乎比在大鼠中强10000倍。[3H]血管加压素的结合研究表明，兔肝细胞膜上完全不存在特异性血管加压素受体。我们证实血管加压素在兔中作为抗利尿和升压剂起作用。我们得出结论，兔肝脏中选择性缺乏V1血管加压素受体。

相似文献

1
Lack of V1 vasopressin receptors in rabbit hepatocytes.兔肝细胞中缺乏V1血管加压素受体。
Biochem J. 1989 Apr 15;259(2):609-11. doi: 10.1042/bj2590609.
2
(3H)-vasopressin binding to isolated rat hepatocytes and liver membranes: regulation by GTP and relation to glycogen phosphorylase activation.（3H）-血管加压素与分离的大鼠肝细胞和肝细胞膜的结合：GTP的调节作用及其与糖原磷酸化酶激活的关系
J Recept Res. 1980;1(2):137-68. doi: 10.3109/10799898009044096.
3
Plasma antidiuretic hormone levels and liver vasopressin receptors in the jerboa, Jaculus orientalis, and rat.东方沙鼠和大鼠的血浆抗利尿激素水平及肝脏血管加压素受体
Gen Comp Endocrinol. 1984 May;54(2):216-29. doi: 10.1016/0016-6480(84)90175-8.
4
[Regulation of glycogenolysis against hormones in isolated rat hepatocytes].[离体大鼠肝细胞中糖原分解对激素的调节作用]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1993 Apr;15(2):123-7.
5
[Regulation of V1-vasopressinergic receptors in the rat].[大鼠中V1-血管加压素能受体的调节]
Arch Mal Coeur Vaiss. 1986 Jun;79(6):824-7.
6
Iodination of vasopressin analogues with agonistic and antagonistic properties: effects on biological properties and affinity for vascular and renal vasopressin receptors.具有激动和拮抗特性的血管加压素类似物的碘化：对生物学特性以及与血管和肾脏血管加压素受体亲和力的影响。
Mol Pharmacol. 1987 Sep;32(3):369-75.
7
Inactivation in vivo of mouse liver glycogen synthase by phenylephrine, vasopressin and glucagon: effect of anaesthesia [proceedings].去氧肾上腺素、血管加压素和胰高血糖素对小鼠肝脏糖原合酶的体内失活作用：麻醉的影响 [会议论文集]
Arch Int Physiol Biochim. 1978 Oct;86(4):961-2.
8
Vasopressin antagonists allow demonstration of a novel type of vasopressin receptor in the rat adenohypophysis.血管加压素拮抗剂可证实在大鼠腺垂体中存在一种新型血管加压素受体。
Mol Pharmacol. 1986 Aug;30(2):171-7.
9
The activation of liver glycogen phosphorylase by vasopressin.血管加压素对肝糖原磷酸化酶的激活作用。
FEBS Lett. 1975 Mar 1;51(1):29-32. doi: 10.1016/0014-5793(75)80848-9.
10
V1-vasopressin receptors in the septum of the rat brain. Electrophysiological evidence.大鼠脑隔区的V1-血管加压素受体。电生理学证据。
J Recept Res. 1988;8(1-4):261-71. doi: 10.3109/10799898809048991.

引用本文的文献

1
Characterization of the human liver vasopressin receptor. Profound differences between human and rat vasopressin-receptor-mediated responses suggest only a minor role for vasopressin in regulating human hepatic function.人肝脏血管加压素受体的特性。人与大鼠血管加压素受体介导的反应之间存在显著差异，这表明血管加压素在调节人类肝脏功能中仅起次要作用。
Biochem J. 1991 May 15;276 ( Pt 1)(Pt 1):189-95. doi: 10.1042/bj2760189.
2
Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes.天然和重组人肝细胞生长因子都是人和大鼠肝细胞中DNA合成的高效促进剂。
J Clin Invest. 1991 May;87(5):1853-7. doi: 10.1172/JCI115207.

本文引用的文献

1
Determination of total protein.总蛋白的测定
Methods Enzymol. 1983;91:95-119. doi: 10.1016/s0076-6879(83)91014-5.
2
Lack of effect of somatostatin on the stimulation of hepatic glycogenolysis by epinephrine in isolated canine hepatocytes.生长抑素对肾上腺素刺激离体犬肝细胞肝糖原分解无作用。
Biochim Biophys Acta. 1984 Aug 17;804(4):414-8. doi: 10.1016/0167-4889(84)90068-5.
3
Lack of vasopressin receptors in liver, but not in kidney, of ob/ob mice.ob/ob小鼠肝脏中缺乏血管加压素受体，但肾脏中不存在这种情况。
Biochem J. 1983 Nov 15;216(2):475-80. doi: 10.1042/bj2160475.
4
The liver angiotensin receptor involved in the activation of glycogen phosphorylase.肝脏血管紧张素受体参与糖原磷酸化酶的激活。
Biochem J. 1982 Dec 15;208(3):809-17. doi: 10.1042/bj2080809.
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Differences between male and female rats in the regulation of hepatic glycogenolysis. The relative role of calcium and cAMP in phosphorylase activation by catecholamines.雄性和雌性大鼠在肝糖原分解调节方面的差异。钙和环磷酸腺苷在儿茶酚胺激活磷酸化酶中的相对作用。
J Biol Chem. 1982 Jul 25;257(14):7987-93.
6
(3H)-vasopressin binding to isolated rat hepatocytes and liver membranes: regulation by GTP and relation to glycogen phosphorylase activation.（3H）-血管加压素与分离的大鼠肝细胞和肝细胞膜的结合：GTP的调节作用及其与糖原磷酸化酶激活的关系
J Recept Res. 1980;1(2):137-68. doi: 10.3109/10799898009044096.
7
The influences of glucagon, epinephrine and alpha- and beta-adrenergic agents on glycogenolysis in isolated rabbit hepatocytes and perfused livers.胰高血糖素、肾上腺素以及α和β肾上腺素能药物对离体兔肝细胞和灌注肝脏中糖原分解的影响。
Biochim Biophys Acta. 1981 May 18;674(3):297-305. doi: 10.1016/0304-4165(81)90360-3.
8
Glycogen-synthase phosphatase activity in rat liver. Two protein components and their requirement for the activation of different types of substrate.大鼠肝脏中的糖原合酶磷酸酶活性。两种蛋白质成分及其对不同类型底物激活的需求。
Eur J Biochem. 1980 Feb;104(1):137-46. doi: 10.1111/j.1432-1033.1980.tb04409.x.
9
A highly sensitive adenylate cyclase assay.一种高灵敏度的腺苷酸环化酶检测方法。
Anal Biochem. 1974 Apr;58(2):541-8. doi: 10.1016/0003-2697(74)90222-x.
10
The vasopressin-sensitive adenylate cyclase of the rat kidney. Effect of adrenalectomy and corticosteroids on hormonal receptor-enzyme coupling.大鼠肾脏中血管升压素敏感的腺苷酸环化酶。肾上腺切除术和皮质类固醇对激素受体 - 酶偶联的影响。
J Biol Chem. 1974 Oct 25;249(20):6390-400.