Tubiana M
Bull Cancer. 1981;68(2):109-15.
Concomitant combined radiotherapy and chemotherapy is less well tolerated by normal tissues than sequential administration. Furthermore, as chemotherapy has to be continued for long periods in order to be effective, the benefits of concomitant administration appear to be minimal in relation to its inconveniences. For sequential treatment, a time interval of one week between the two therapies can reduce cumulative toxic effects on normal tissues. Moreover it is preferable to administer each of them as early as possible to reduce the risk of the development of resistant tumoral cells. A treatment schedule is proposed in which chemotherapy is started as soon as possible with the conventional scheduling of one cycle every month. Radiotherapy is given one week after interrupting chemotherapy, and continued until one week before beginning further cycle of chemotherapy. It is then reinstituted on week after the end of this course, and continued until all tissues have been sufficiently irradiated.
与序贯给药相比，同步放化疗对正常组织的耐受性较差。此外，由于化疗必须持续很长时间才能起效，同步给药的益处与其带来的不便相比似乎微不足道。对于序贯治疗，两种疗法之间间隔一周的时间可以减少对正常组织的累积毒性作用。此外，最好尽早分别给予两种治疗，以降低耐药肿瘤细胞产生的风险。提出了一种治疗方案，即尽快开始化疗，按照传统方案每月进行一个周期。放疗在化疗中断一周后进行，并持续到下一轮化疗开始前一周。然后在本疗程结束后的一周重新开始化疗，并持续到所有组织都得到充分照射。
