Arriagada R, Le Chevalier T, Sillet-Bach I
Bull Cancer. 1981;68(2):163-5.
Thirteen patients with inoperable squamous cell lung cancer were treated by a protocol combining multiple chemotherapy with radiotherapy. Chemotherapy with Adriamycine, Vinblastine, Cyclophamide, Methotrexate and Cis-platinum was administered every month, followed by two radiotherapy sessions with doses of mediastinum. Six cycles were programmed. In 11 non-metastatic patients, 8 responses were obtained (4 objective remissions). Three developed distant metastases. However, mean survival (27 weeks) and 1 year survival (2/10) rates were disappointing. Multiple chemotherapy could be useful in decreasing tumoral size before radiotherapy, modalities of combined treatment should be studied.
13例无法手术的肺鳞状细胞癌患者接受了多药化疗联合放疗的方案治疗。每月给予阿霉素、长春碱、环磷酰胺、甲氨蝶呤和顺铂进行化疗，随后进行两程纵隔放疗。计划进行6个周期。在11例无转移的患者中，有8例有反应（4例客观缓解）。3例出现远处转移。然而，平均生存期（27周）和1年生存率（2/10）令人失望。多药化疗在放疗前减小肿瘤大小方面可能有用，联合治疗的方式应进一步研究。
