2型单纯疱疹病毒在抗性和敏感近交系小鼠品系中诱导自然杀伤细胞的产生。

Induction of natural killer cells by herpes-simplex virus type 2 in resistant and sensitive inbred mouse strains.

作者信息

Armerding D, Rossiter H

出版信息

Immunobiology. 1981;158(4):369-79. doi: 10.1016/S0171-2985(81)80007-1.

Abstract

Infection of mice with herpes simplex virus type 2 (HSV 2) stimulated natural killer (NK) cells in a variety of inbred mouse strains including athymic nude mice. Essentially all mouse strains tested exhibited high NK activity on day four after virus inoculation. Assayed 24 hours after infection, SWR/J, AKR/J, SJL/J and C57B1/10J mice were low or negative for these non-virus-specific cytotoxic responses. Whereas the first two mouse strains were most sensitive to the lethal effects of HSV 2, the latter two were highly resistant. Three lines with intermediate susceptibility and three highly resistant strains were all efficient with regard to early NK-cell.

摘要

用2型单纯疱疹病毒（HSV 2）感染小鼠可刺激多种近交系小鼠（包括无胸腺裸鼠）的自然杀伤（NK）细胞。基本上所有测试的小鼠品系在病毒接种后第4天均表现出高NK活性。在感染后24小时进行检测时，SWR/J、AKR/J、SJL/J和C57B1/10J小鼠的这些非病毒特异性细胞毒性反应较低或呈阴性。前两个小鼠品系对HSV 2的致死作用最敏感，而后两个则具有高度抗性。三个具有中等易感性的品系和三个高度抗性的品系在早期NK细胞方面均表现良好。