Scriba M, Tatzber F
Infect Immun. 1981 Dec;34(3):655-61. doi: 10.1128/iai.34.3.655-661.1981.
The pathogenesis of herpes simplex virus types 1 and 2 has been studied in guinea pigs after inoculation by various routes (subcutaneous and intradermal infection in footpads and vaginal infection). Clinical observations as well as virus isolation studies are reported. Herpes simplex virus type 2 infection by all three routes of inoculation led to acute primary and recurrent lesions. Virus persisted in the nervous system, particularly in sensory ganglia, and locally at the site of inoculation. Herpes simplex virus type 1 infection induced no or very mild primary symptoms. Recurrent lesions were only observed after intradermal inoculation. Invasion of the nervous system and consequent establishment of latent ganglionic infection was less efficient than after herpes simplex virus type 2 infection. Peripheral persistence was, however, equally common.
通过多种途径（足垫皮下和皮内感染以及阴道感染）接种豚鼠后，对1型和2型单纯疱疹病毒的发病机制进行了研究。报告了临床观察结果以及病毒分离研究。通过所有三种接种途径感染2型单纯疱疹病毒均导致急性原发性和复发性病变。病毒在神经系统中持续存在，尤其是在感觉神经节中，并在接种部位局部存在。1型单纯疱疹病毒感染未引起或仅引起非常轻微的原发性症状。仅在皮内接种后观察到复发性病变。与2型单纯疱疹病毒感染后相比，1型单纯疱疹病毒感染对神经系统的侵袭以及随后潜伏性神经节感染的建立效率较低。然而，外周持续性同样常见。
