Spoerri P E
J Hirnforsch. 1981;22(1):85-92.
Ultrastructural features of cytodifferentiation in monolayer cultures of mouse neuroblastoma cells (clone neuro-2A) was further characterized by the presence of annulate lamellar arrays with up to 10 lamellae. The lamellae were made up of fused smooth surfaced cisternae forming pores or annuli and were surrounded by a dense filamentous to granular material. Stacks of nonfenestrated, parallel, regularly spaced cisternae, designated as lamellar bodies, also appeared in the cytoplasm in association with the endoplasmic reticulum and the nucleus. Such flattened cisternae were also seen to be formed from transformed endoplasmic reticulum. Furthermore a relatively large number of concentric whorled lamellar bodies were presented as well as dense whorled structures reminiscent of the cytoplasmic laminar bodies. All of these structures are derived from the rough endoplasmic reticulum, the tubules of which are coexistent with those of the latter. In addition there is a topographic relationship of these bodies with mitochondria and with the nucleus. There is a relative persistence of most of these organelles in old or atropic cells which show marked changes including loss of endoplasmic reticulum. The significance of all of these cytoplasmic inclusions is discussed.
小鼠神经母细胞瘤细胞（克隆神经-2A）单层培养中细胞分化的超微结构特征，进一步表现为存在多达10个板层的环状板层阵列。这些板层由融合的光滑表面潴泡形成孔或环，并被致密的丝状至颗粒状物质包围。成叠的无窗孔、平行、规则间隔的潴泡，即板层体，也出现在细胞质中，与内质网和细胞核相关。这种扁平潴泡也被认为是由转化的内质网形成的。此外，还出现了相对大量的同心螺旋板层体以及致密的螺旋结构，让人联想到细胞质层状体。所有这些结构都源自粗面内质网，其小管与后者的小管共存。此外，这些小体与线粒体和细胞核存在拓扑关系。在衰老或萎缩细胞中，这些细胞器大多相对持久，这些细胞表现出明显变化，包括内质网的丧失。文中讨论了所有这些细胞质内含物的意义。
