Seay A R, Griffin D E, Johnson R T
Neurology. 1981 Jun;31(6):656-60. doi: 10.1212/wnl.31.6.656.
Ross River virus (RRV) causes an age-dependent myositis in mice. Infected 4-week-old mice develop no clinical signs, but 1-week-old mice develop weakness and myositis. Humoral and cell-mediated immune responses to RRV in the two age groups are comparable, and immunosuppression does not alter age-dependent resistance to clinical disease. Immunosuppression of 1-week-old mice protracts clinical signs and reduces muscle inflammation but does not alter muscle necrosis or regeneration. These studies suggest that immune responses do not determine age dependency of RRV myositis and that muscle necrosis results from direct viral lysis of muscle fibers.
罗斯河病毒（RRV）可在小鼠中引发年龄依赖性肌炎。4周龄的感染小鼠未出现临床症状，但1周龄的小鼠出现了肌无力和肌炎症状。两个年龄组对RRV的体液免疫和细胞介导免疫反应相当，免疫抑制不会改变对临床疾病的年龄依赖性抵抗力。对1周龄小鼠进行免疫抑制会延长临床症状并减轻肌肉炎症，但不会改变肌肉坏死或再生情况。这些研究表明，免疫反应并非RRV肌炎年龄依赖性的决定因素，且肌肉坏死是由病毒对肌纤维的直接裂解所致。
