Seay A R, Kern E R, Murray R S
Neurology. 1987 Jul;37(7):1189-93. doi: 10.1212/wnl.37.7.1189.
Ross River virus (RRV), an alpha togavirus, causes an inflammatory myopathy in mice, which probably results from direct lytic effects of virus or viral products on myofibers. Administration of recombinant hybrid human leukocyte interferon-alpha A/D (rIFN-alpha A/D) ameliorates clinical illness and reduces mortality from 86 to 42%. Peak concentrations of virus are reduced by 1,000-fold in serum and by 30-fold in muscle, but anti-RRV antibody production is not altered. Treatment with rIFN-alpha A/D dramatically reduces inflammation and necrosis in muscle. Beneficial effects of rIFN-alpha A/D on experimental, RRV-induced polymyositis result in part from inhibition of viral replication and spread, though immunomodulation might also play an important role.
罗斯河病毒（RRV），一种α-披膜病毒，可在小鼠中引起炎性肌病，这可能是由于病毒或病毒产物对肌纤维的直接溶解作用所致。给予重组杂交人白细胞干扰素-αA/D（rIFN-αA/D）可改善临床疾病，并将死亡率从86%降低至42%。血清中病毒的峰值浓度降低了1000倍，肌肉中降低了30倍，但抗RRV抗体的产生没有改变。用rIFN-αA/D治疗可显著减轻肌肉中的炎症和坏死。rIFN-αA/D对实验性RRV诱导的多发性肌炎的有益作用部分源于对病毒复制和传播的抑制，尽管免疫调节可能也起重要作用。
