Chalas J, Labayle D, Lindenbaum A, Cluet J L, Godin J, Leluc R, Etienne J P
Pathol Biol (Paris). 1981 Mar;29(3):163-8.
In cirrhotic, steatosic and healthy subjects, the authors studied the metabolism of disulfiram (TETD) administrated orally (500 mg) 3 consecutive days. Carbon disulfide (CS2) and the whole TETD, diethyl dithiocarbamate (DDC) disulfides, were determined by a gas chromatographic method. The evolution of metabolites is similar in steatosic and healthy subjects. In cirrhotics the CS2, DDC and disulfides level increase within the 3 days. This phenomenon may be related with hepatic toxicity of TETD and with the persistence of disulfiram-alcohol reaction. The authors suggest to use low doses of disulfiram in cirrhotic.
在肝硬化患者、脂肪肝患者和健康受试者中，作者研究了连续3天口服（500毫克）双硫仑（TETD）后的代谢情况。采用气相色谱法测定二硫化碳（CS2）以及整个TETD、二乙基二硫代氨基甲酸盐（DDC）二硫化物。脂肪肝患者和健康受试者中代谢产物的变化相似。在肝硬化患者中，CS2、DDC和二硫化物水平在3天内升高。这种现象可能与TETD的肝毒性以及双硫仑-酒精反应的持续存在有关。作者建议在肝硬化患者中使用低剂量的双硫仑。
