Alexandrova A E, Vasiliev A V, Greimer M S, Zabolotnîh N V, Kniajeţkaia E J, Kozlova N V, Talanova A G, Scerbakova N M
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1981 Apr-Jun;30(2):115-22.
Thymus grafts, in semi-permeable chambers, from 7-10 day old white rats to guinea-pigs infected with M. tuberculosis, or to white rats that had underwent thymectomy and had been infected, is accompanied by a considerable decrease in the severity of the tuberculous process. A similar effect is obtained by the subcutaneous injection of a thymus preparation called Timalin. The addition to etiotropic therapy of the immunostimulant Levamisole in amounts of 2,5 mg/kg of body weight in white rats, and of 25 mg/kg of body weight in guinea-pigs, three times during a decade significantly enhanced the effect of the conventional therapy. Levamisole, when included in the complex therapy of tuberculosis patients (three times during a decade), accelerated the detoxification process, and the recovery of recent destructive lesions in the lung. In animals and in patients Levamisole increases the low activity of the T-lymphocytes immune system, as is indicated by data obtained with the leucocyte migration inhibition test, and with the rosette-formation test.
将7 - 10日龄白色大鼠的胸腺移植到感染结核分枝杆菌的豚鼠或已接受胸腺切除术并已被感染的白色大鼠体内，置于半透性小室中，结核病变的严重程度会显著降低。皮下注射一种名为Timalin的胸腺制剂也能获得类似效果。在白色大鼠中，以2.5毫克/千克体重、在豚鼠中以25毫克/千克体重的剂量，在十年内分三次添加免疫刺激剂左旋咪唑到病因疗法中，可显著增强传统疗法的效果。当左旋咪唑被纳入结核病患者的综合治疗中（十年内分三次）时，可加速解毒过程以及肺部近期破坏性病变的恢复。如白细胞迁移抑制试验和玫瑰花结形成试验所获得的数据所示，在动物和患者中，左旋咪唑可提高T淋巴细胞免疫系统的低活性。
