Karachunskiĭ M A, Gergert V Ia, Iakovleva O B
Probl Tuberk. 1997(6):59-60.
The parameters of cellular immunity were studied in 64 patients with pulmonary tuberculous developed in the presence of type 1 diabetes mellitus and compared with those in 36 patients with pulmonary tuberculosis alone. Patients with concomitant abnormalities showed higher depression of cellular immunity appeared as fewer T lymphocytes and their decreased capacity for blast-cell transformation than those with tuberculosis alone. Immunological parameters became normal only due to complex chemo- and immunotherapies (with T-activin). In addition, treatment outcomes improve and more rapid and frequent abacillation occurs. The development of tuberculosis in patients with diabetes mellitus is an additional indication for immunostimulant therapy with T-activin.
对64例1型糖尿病合并肺结核患者的细胞免疫参数进行了研究,并与36例单纯肺结核患者的细胞免疫参数进行了比较。合并异常的患者细胞免疫抑制程度更高,表现为T淋巴细胞数量减少,其母细胞转化能力下降,而单纯肺结核患者则不然。免疫参数仅通过综合化学和免疫疗法(使用T-激活素)才恢复正常。此外,治疗效果改善,脱痂更快且更频繁。糖尿病患者发生结核病是使用T-激活素进行免疫刺激治疗的另一个指征。