Grigor'eva S P, Kniazeva G D, Ots O N
Vopr Onkol. 1981;27(5):27-34.
The results of surgical treatment of 36 patients suffering from undifferentiated small-cell carcinoma of lung are discussed. During the first two years, 28 patients (78%) died as a result of tumor progression, while 8 patients (22%) survived for 3--20 years after operation. Retrospective study established that the majority of the patients had a small -- size peripheral tumor without metastases in regional lymph nodes. Histological examination revealed a considerable development of stroma having a structure of mature fibrous tissue, few mitoses and no necroses. The findings show that in some cases of early stages of undifferentiated small-cell carcinoma of the lung, surgery may assure a long survival of tumor patients.
本文讨论了36例未分化型肺小细胞癌患者的外科治疗结果。在最初两年中，28例患者（78%）因肿瘤进展死亡，而8例患者（22%）术后存活了3至20年。回顾性研究表明，大多数患者的肿瘤为小尺寸周围型，区域淋巴结无转移。组织学检查显示，基质有相当程度的发展，呈成熟纤维组织结构，有少量有丝分裂，无坏死。研究结果表明，在某些未分化型肺小细胞癌早期病例中，手术可确保肿瘤患者长期存活。
