Buddingh F, Bailey M J, Wells B, Haesemeyer J
Am Ind Hyg Assoc J. 1981 Jul;42(7):503-9. doi: 10.1080/15298668191420152.
Desorption of benzo(alpha)pyrene from commercial carbon blacks by tissue fluids in vitro is compared to arylhydrocarbon hydroxylase induction in mice at three levels of carbon black exposure. Less than 0.005% of the adsorbed benzo(alpha)pyrene content determined by soxhlet extraction in toluene is eluted by human plasma, swine serum, swine lung homogenate and swine lung washings. Statistically significant differences in elution efficiency are observed by the various tissue fluids and carbon blacks. There is no detectable increase in AHH level in mouse lung or liver tissues even at the highest carbon black exposure and consumption rate of 1g/g bdywt/year.
在体外，将三种炭黑暴露水平下商业炭黑中苯并（α）芘被组织液的解吸情况与小鼠体内芳烃羟化酶的诱导情况进行了比较。用索氏提取法测定的甲苯中吸附的苯并（α）芘含量，被人血浆、猪血清、猪肺匀浆和猪肺冲洗液洗脱的比例不到0.005%。不同组织液和炭黑在洗脱效率上存在统计学上的显著差异。即使在最高炭黑暴露水平和1克/克体重/年的摄入量下，小鼠肺或肝组织中的芳烃羟化酶水平也没有可检测到的增加。
