Kapitanova N G, Korepanova E A, Kolesova G M, Antonov V F
Biokhimiia. 1980 Sep;45(9):1682-4.
the mechanism of the effect of the peptide antibiotic polymixin B on respiration of rat liver mitochondria was studied. It was shown that polymixin B at concentrations of (1,6--2,0) . 10(-3) M inhibits mitochondrial respiration in state 3 and 3u irrespective of the oxidation substrate used and activates oxygen consumption in state 4 at lower concentrations. It is assumed that the antibiotic affects mitochondrial respiration by changing the ionic permeability of the membranes.
研究了肽抗生素多粘菌素B对大鼠肝线粒体呼吸作用的影响机制。结果表明，浓度为(1.6 - 2.0)×10⁻³ M的多粘菌素B无论使用何种氧化底物，均可抑制状态3和状态3u下的线粒体呼吸，并在较低浓度时激活状态4下的氧消耗。推测该抗生素通过改变膜的离子通透性来影响线粒体呼吸。
