[多粘菌素B对细菌细胞膜离子通透性的影响]

[Effect of polymyxin B on ion permeability of bacterial membranes].

作者信息

Kapitanova N G, Korepanova E A, Gariaev A A, Frolov V N, Antonov V F

出版信息

Biofizika. 1981 Nov-Dec;26(6):1100-2.

Abstract

Effect of polymyxin B on the movement of K+ and H+ in polymyxin-sensitive cells of E. coli under different metabolic states has been studied. It was shown that polymyxin B induced the efflux of K+, decreased the efflux of H+ and inhibited the consumption of oxygen in bacterial cells. The effect of antibiotic on ion movement was independent of respiratory conditions. It was suggested that polymyxin B increased ion permeability and destroyed lipid-protein interactions of the respiratory chain simultaneously.

摘要

研究了多粘菌素B对处于不同代谢状态的大肠杆菌多粘菌素敏感细胞中钾离子（K⁺）和氢离子（H⁺）转运的影响。结果表明，多粘菌素B可诱导K⁺外流，减少H⁺外流，并抑制细菌细胞中的耗氧量。抗生素对离子转运的影响与呼吸条件无关。有人提出，多粘菌素B可增加离子通透性并同时破坏呼吸链的脂蛋白相互作用。