Greer C A, Stewart W B, Kauer J S, Shepherd G M
Brain Res. 1981 Aug 3;217(2):279-93. doi: 10.1016/0006-8993(81)90004-4.
Experiments were carried out to examine the topographical projection of the olfactory nerves to the olfactory bulb in the rat, using the Sokoloff [14C]2-deoxyglucose (2-DG) technique. Electrical stimulation of a medially located bundle of olfactory nerves produced a discrete zone of 2-DG uptake at the rostral pole of the bulb. Increasing stimulus strength yielded a slightly larger focus at this site. In contrast, electrical stimulation of laterally situated bundles of olfactory nerves resulted in a broad zone of activity extending along the lateral wall of the bulb, and increasing stimulus intensity produced a more extensive area of uptake. Laminar analyses provided information on the relation between activity in the glomerular layer, where the olfactory nerves terminate, and activity in deeper layers. The results support previous studies of the topographical projections of the olfactory nerves to the olfactory bulb. They also support the hypothesis that odor-induced 2-DG uptake in the olfactory bulb represents activation of groups of receptors in the olfactory epithelium whose axons terminate in activated glomerular regions in the olfactory bulb.
利用索科洛夫[14C]2-脱氧葡萄糖（2-DG）技术，进行了实验以研究大鼠嗅神经向嗅球的拓扑投射。对位于内侧的一束嗅神经进行电刺激，在嗅球的嘴侧极产生了一个离散的2-DG摄取区。增加刺激强度会在该部位产生稍大的聚焦区。相比之下，对位于外侧的一束束嗅神经进行电刺激，会导致一个沿着嗅球外侧壁延伸的广泛活动区，增加刺激强度会产生更广泛的摄取区域。分层分析提供了有关嗅神经终止的肾小球层活动与更深层活动之间关系的信息。这些结果支持了先前关于嗅神经向嗅球拓扑投射的研究。它们还支持这样的假设，即嗅球中气味诱导的2-DG摄取代表嗅觉上皮中轴突终止于嗅球中活化肾小球区域的受体组的激活。
