Vitorica J, Satrústegui J, Machado A
Enzyme. 1981;26(3):144-52. doi: 10.1159/000459164.
The variations in enzyme activities involved in the main pathways of liver energetic metabolism--glycolysis, Krebs cycle, gluconeogenesis and lipogenesis--have been studied in rats ranging between the age of 4 days and 21 months. The major changes observed are the following: (1) enzymes involved in glycolysis (pyruvate kinase) and lipogenesis (NADP-malic enzyme, ATP-citrate lyase) decrease in activity during ageing, and (2) gluconeogenic enzymes (phosphoenolpyruvate carboxykinase, glucose-6-phosphatase) are maintained or slightly increased over the same period. The results suggest that an increase in the capacity for gluconeogenesis with respect to that for lipogenesis takes place in the aged rat liver.
在4日龄至21月龄的大鼠中，研究了肝脏能量代谢主要途径（糖酵解、三羧酸循环、糖异生和脂肪生成）中所涉及的酶活性变化。观察到的主要变化如下：（1）参与糖酵解的酶（丙酮酸激酶）和脂肪生成的酶（NADP-苹果酸酶、ATP-柠檬酸裂解酶）在衰老过程中活性降低；（2）在同一时期，糖异生酶（磷酸烯醇丙酮酸羧激酶、葡萄糖-6-磷酸酶）活性保持不变或略有增加。结果表明，老年大鼠肝脏中糖异生能力相对于脂肪生成能力有所增加。
