Helmeste D M, Seeman P, Coscina D V
Eur J Pharmacol. 1981 Feb 19;69(4):465-70. doi: 10.1016/0014-2999(81)90450-7.
In order to examine the potential relation between behaviour elicited by apomorphine and the density of catecholamine receptors, we studied stereotypy and the binding of [3H]spiperone to D2-(or neuroleptic/dopamine) receptors, of [3H]WB-4101 to alpha1-adrenoceptors, and [3H]clonidine to alpha2-adrenoceptors in two strains of rats. The F344 rats exhibited significantly more stereotypy to apomorphine than the Buffalo strain of rats. Other F344 rats which did not receive apomorphine and 34% more D2-receptors in the striatum and 50% more D2-receptors in the olfactory tubercle. Alpha2-Receptors in the frontal cortex were 20% higher in F344 rats when compared to the Buffalo strain, while alpha 1-receptors were the same across both strains. These results suggest a relation between D2-dopamine/neuroleptic receptor density and behavioural responsiveness to the direct-acting and specific dopamine agonist, apomorphine.
为了研究阿扑吗啡引发的行为与儿茶酚胺受体密度之间的潜在关系，我们在两种品系的大鼠中研究了刻板行为以及[3H]司哌啶与D2（或抗精神病药/多巴胺）受体、[3H]WB-4101与α1-肾上腺素能受体、[3H]可乐定与α2-肾上腺素能受体的结合情况。F344大鼠对阿扑吗啡表现出的刻板行为明显多于布法罗品系大鼠。其他未接受阿扑吗啡的F344大鼠，其纹状体中的D2受体多34%，嗅结节中的D2受体多50%。与布法罗品系相比，F344大鼠额叶皮质中的α2受体高20%，而两种品系的α1受体相同。这些结果表明D2-多巴胺/抗精神病药受体密度与对直接作用的特异性多巴胺激动剂阿扑吗啡的行为反应性之间存在关联。
