Spirduso W W, Gilliam P, Wilcox R E
Psychopharmacology (Berl). 1984;83(2):205-9. doi: 10.1007/BF00429736.
Speed of movement initiation is altered in normal aging and in neurological disorders such as Parkinson's disease. This study was undertaken to extend our previous results, which suggested a relationship between nigrostriatal dopamine function and an animal model of movement initiation speed (reactive capacity). Fisher 344 rats exhibiting exceptionally fast or slow reactive capacity but otherwise normal were examined for differences in the striatal binding of the dopaminergic ligand, [3H]spiroperidol. Rats with fast reactive capacity (Fast rats) exhibited significantly higher binding than did rats with slow reactive capacity (Slow rats). Also, Fast rats responded nearly maximally on the reactive capacity task regardless of the duration of time provided in which to respond, whereas Slow rats reacted more slowly when more response time was provided. The differences in [3H]spiroperidol binding and the differential influence of time provided to respond on the response latency of these two normal groups of rats was similar to that observed in old or model Parkinson's disease rats having nigrostriatal dopamine deficits. These results strengthen the relationship between an animal model of reactive capacity and nigrostriatal dopamine function.
在正常衰老以及帕金森病等神经疾病中，运动启动速度会发生改变。本研究旨在拓展我们之前的研究结果，之前的研究表明黑质纹状体多巴胺功能与运动启动速度（反应能力）的动物模型之间存在关联。对反应能力异常快或慢但其他方面正常的Fisher 344大鼠进行检查，以观察多巴胺能配体[3H]螺哌啶在纹状体结合上的差异。反应能力快的大鼠（快反应大鼠）的结合水平显著高于反应能力慢的大鼠（慢反应大鼠）。此外，无论给予多长时间来做出反应，快反应大鼠在反应能力任务上的反应几乎都达到最大值，而当给予更多反应时间时，慢反应大鼠的反应则更慢。这两组正常大鼠在[3H]螺哌啶结合上的差异以及给予反应时间对反应潜伏期的不同影响，与在黑质纹状体多巴胺缺乏的老年大鼠或帕金森病模型大鼠中观察到的情况相似。这些结果强化了反应能力动物模型与黑质纹状体多巴胺功能之间的关系。
