氟哌啶醇和Δ⁹-四氢大麻酚对免疫反应性的改变。
Alterations of immune reactivity by haloperidol and delta-9-tetrahydrocannabinol.
作者信息
Levy J A, Heppner G H
出版信息
J Immunopharmacol. 1981;3(1):93-109. doi: 10.3109/08923978109026421.
Studies were performed to determine whether delta 9-tetrahydrocannabinol (THC) or haloperidol suppress or ablate humoral or cellular immune responses against sheep erythrocytes. Both agents produced dose-dependent reductions in hemolytic plaque-forming cell (PFC) numbers at the time or peak reactivity (Day 4) in vehicle-treated, control mice. However, both delta 9-THC and haloperidol only delayed the time of peak PFC formation by 24-48 hours. These changes in kinetics of humoral immune responsiveness took place at doses of delta 9-THC and haloperidol that produced signs of gross behavioral toxicity. Neither Delta-9-THC, cannabinol (CBN) or cannabidiol (CBD) had an effect on the titer of serum hemagglutinating antibody measured seven days after immunization. Further, haloperidol did not alter the delayed-type hypersensitivity response to dinitroflorobenzene (DNFB).
开展了多项研究以确定Δ⁹-四氢大麻酚（THC）或氟哌啶醇是否会抑制或消除针对绵羊红细胞的体液免疫或细胞免疫反应。在给予赋形剂处理的对照小鼠中，两种药物在反应峰值时（第4天）均使溶血空斑形成细胞（PFC）数量呈剂量依赖性减少。然而，Δ⁹-THC和氟哌啶醇均仅将PFC形成峰值时间延迟了24 - 48小时。体液免疫反应动力学的这些变化发生在产生明显行为毒性迹象的Δ⁹-THC和氟哌啶醇剂量下。免疫后7天测量的血清血凝抗体效价，Δ⁹-THC、大麻酚（CBN）或大麻二酚（CBD）均无影响。此外，氟哌啶醇并未改变对二硝基氟苯（DNFB）的迟发型超敏反应。
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