Sordillo P, Sagransky D M, Mercado R M, Michelis M F
Arch Intern Med. 1978 Feb;138(2):299-301.
The syndrome of inappropriate antidiuretic hormone secretion, with marked hyponatremia, was observed in an elderly women who was taking carbamazepine for trigeminal neuralgia. Subsequent studies revealed this effect to be directly related to the administration of the drug. Substantial water retention has not been previously described in patients taking normal volumes of fluid and taking standard doses of carbamazepine. Additionally, it was determined that the antidiuretic effect of carbamazepine could be blocked by phenytoin. The actions of both drugs on renal water excretion, and the interactions of the drugs were observed to be dose-related.
一名老年女性因三叉神经痛服用卡马西平，出现了抗利尿激素分泌不当综合征，并伴有显著低钠血症。后续研究表明，这种效应与药物的使用直接相关。此前尚未有服用正常量液体和标准剂量卡马西平的患者出现大量水潴留的报道。此外，已确定苯妥英可阻断卡马西平的抗利尿作用。观察到两种药物对肾脏水排泄的作用以及药物间的相互作用与剂量相关。
