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谷氨酸脱羧酶在猴纹状皮质中的免疫细胞化学定位

Immunocytochemical localization of glutamic acid decarboxylase in monkey striate cortex.

作者信息

Hendrickson A E, Hunt S P, Wu J Y

出版信息

Nature. 1981 Aug 13;292(5824):605-7. doi: 10.1038/292605a0.

DOI:10.1038/292605a0
PMID:6265804
Abstract

Neuronal cell bodies and synaptic terminals positive for glutamic acid decarboxylase, the enzyme responsible for synthesizing gamma-amino butyric acid, have been located by immunocytochemical staining in all layers of the macaque monkey cortex. In layers II and III the staining pattern of periodic dots is identical with that seen in sections stained for cytochrome oxidase. The rows of dots run parallel with the ocular dominance columns, suggesting that the labelled neurones are preferentially related to each eye.

摘要

通过免疫细胞化学染色,在猕猴大脑皮层的所有层中都定位到了谷氨酸脱羧酶呈阳性的神经元细胞体和突触终末,谷氨酸脱羧酶是负责合成γ-氨基丁酸的酶。在第II层和第III层中,周期性点状的染色模式与细胞色素氧化酶染色切片中所见的相同。点状排列与眼优势柱平行,这表明标记的神经元优先与每只眼睛相关。

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